Department of Clinical Genetics

Greetings

Regarding the medical services of our department

[Cancer genomic medicine] → Please refer to the medical department website.

[Diagnosis and treatment of hereditary diseases (especially hereditary tumors)]

１. Diagnosis and treatment of hereditary tumors

Characteristics of hereditary tumor patients include multiple cases of the same cancer (multiple occurrences), carcinogenesis of various organs (multiplicity), carcinogenesis during youth (youth onset), or when there are many cases of cancer in a family (family clustering), etc. Not only does this require appropriate diagnosis, treatment, and regular health management of the patients themselves, but also appropriate surveillance may be necessary for relatives with the same conditions. Typical hereditary tumors can be genetically diagnosed with genetic test using blood samples. Although genetic diagnosis of patients with some hereditary tumors is done at their own cost, some diseases can also be done as research.
We also support patients and their families who have found hereditary tumors through precision cancer medicine such as cancer genome gene panel testing, etc.
Our department consults on the following hereditary tumors, but we may refer to other medical departments for the actual medical care and examinations.

Hereditary tumors that can be supported

Lynch syndrome

Lynch syndrome patients and their families are at an elevated risk of developing various malignancies, including colorectal cancer and endometrial cancer.

Familial colorectal adenomatosis (familial colorectal polyposis)

This disease is characterized by the development of multiple colorectal polyps. If not treated, almost all familial colorectal adenomatosis patients develop colorectal cancer.

Hereditary breast cancer / ovarian cancer syndrome

This is a predisposition that makes someone susceptible to breast cancer and ovarian cancer.
It is also associated with increased risk of pancreatic cancer and prostate cancer.

Other

• Peutz‐Jeghers' syndrome
• Juvenile polyposis syndrome
• Cowden/hamartoma syndrome
• Li-Fraumeni syndrome
• Multiple endocrine neoplasia, MEN
• Hereditary Diffuse Gastric Cancer, HDGC
• Other familial clustering tumor syndromes

Please feel free to contact us if you have any questions about cancer and heredity, such as:
Many of my family and relatives have suffered from cancer, and I'm worried that I’m going to have cancer too, or
Many of my family and relatives have suffered from cancer, and I'm worried that I’m going to have cancer too, or

2. Diagnosis and treatment of non-tumor hereditary diseases

　We can consult about hereditary metabolic diseases and neurological disorders in adults, excluding obstetrics and pediatrics. Although we do not perform genetic diagnosis, treatment, or periodic examination of these non-tumor hereditary diseases, we can refer to medical departments in the hospital and other medical institutions.

Clinical genetic specialists and familial oncologists are in charge of the treatment, and a dedicated certified genetic counselor provides genetic counseling.
Genetic diagnosis and genetic counseling fees: in general,at the patient’s own cost (except when participating in research)

Target diseases and target symptoms

[Cancer genomic medicine]

Target patients

1. In the case of medical treatment covered by insurance

• Rare cancers, cancers with unknown origin, and cancers where standard treatment has ended
• Those whose physical condition is such that they can continue to receive drug therapy (anticancer drugs, molecular target drugs, etc.)

2. In the case of medical treatment at the patient’s own expense

There are no special restrictions on the type, stage, or condition of the cancer.

[Other hereditary tumors]

Lynch syndrome

This is a predisposition that causes susceptibility to colon cancer.
In addition to having colon cancer, these patients have been found to be susceptible to endometrium cancer (endometrial cancer), and stomach cancer, etc.

Familial colorectal adenomatosis (familial colorectal polyposis)

This is a predisposition that causes susceptibility to colon cancer.
This is characterized by frequent polyps in the large intestine and stomach from a young age.

Hereditary breast cancer ovarian cancer syndrome

This is a predisposition that causes susceptibility to breast cancer and ovarian cancer.
It is also said to increase the risk for pancreatic cancer and prostate cancer in men.

Other

• Peutz‐Jeghers'syndrome
• Juvenile polyposis syndrome
• Cowden/hamartoma syndrome
• Li-Fraumeni syndrome
• Multiple endocrine neoplasia, MEN
• Hereditary Diffuse Gastric Cancer, HDGC
• Other familial clustering tumor syndromes

Target Symptoms

There may be cases with various symptoms, or there may be no symptoms. Also, there are some, even among those who are susceptible to hereditary diseases, who have not yet developed or do not have the disease, and some who will not develop it for the rest of their lives.

Payment Information

■Regarding genetic counseling costs

　The genetic counseling fee is 5,500 yen (including tax) per visit.
Counseling may be done as research depending on the disease.

■Regarding the cost of cancer genomic medicine, please refer to the application method for cancer genomic medicine on the medical department website.

Medical staff

Outpatient clinic

水曜日 午前 （9:00-11:30）
・がんゲノム医療受診前調査 ・遺伝性腫瘍外来
水曜日 午後 （13:00-16:00）
・がんゲノム医療外来
・遺伝性疾患外来
担当医：石田 秀行、鈴木 興秀、母里 淑子
担当遺伝カウンセラー：田辺 記子、構 奈央
その他の曜日をご希望の場合は個別にご相談ください。
当外来は予約制になっております。患者さんご本人または主治医の先生より当科スタッフまでご連絡ください。

Wednesday Morning (9:00 am - 11:30 am)
・ Cancer genomic medicine pre-examination
Wednesday Afternoon (1:00 pm - 4:00 pm)
・ Cancer genomic medicine outpatient
・ Hereditary disease outpatient
Physicians in charge: Hideyuki Ishida, Okihide Suzuki, Yoshiko Mori
Genetic Counselor in charge: Nao Kamae
Please contact us individually if you would like to meet on another day of the week.
Our outpatient is by reservation only. Patients themselves or their doctors can contact our staff.

To Medical Institutions

[Overview of outpatient application method for cancer genomic medicine]Please go to the Medical Department website for details and application documents.

Target patients of cancer gene tests

These are basically patients with rare cancers, cancers with unknown origin, and cancers where standard treatment has ended.
Those who are in good physical condition (ECOG PS = 2 or less) and who can continue drug therapy (anti-cancer drugs and molecular targeted drugs) are eligible.
This applies to patients who are ineligible for or expected to be intolerant of standard treatment.

For conditions other than the above, patients should please contact us individually.

Contact us:049-228-3619