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| Year | Month | Details |
|---|---|---|
| 1972 | - | Acquired land in Kamoda District, Kawagoe City |
| 1989 | 2 | Construction on the General Medical Center started |
| 1985 | 3 | Saitama Medical Center completed |
| 3 | Duty Center (Margaret I) completed | |
| 4 | Saitama Medical Center, School of Nursing opened | |
| 6 | Saitama Medical Center opened (number of beds 792) | |
| 1987 | 3 | Research duty building (Margaret II) completed |
| 4 | Department of Emergency and Critical Care Medicine opened | |
| 1989 | 4 | Kawagoe Nursery School opened |
| 6 | Extracorporeal shockwave lithotripsy operation started | |
| 1992 | 6 | East MR Room operation started |
| 1994 | 4 | Kawagoe City Medical Association Disease Diagnosis Cooperation Project |
| 1995 | 6 | Hospital 10th anniversary |
| 1996 | 3 | Establishment of the Department of Health Promotion (Ningen Dock) |
| 9 | ICU Opened | |
| 11 | Center for Maternal-Fetal and Neonatal Medicine opened | |
| 1997 | 2 | First research building opening ceremony |
| 3 | West MR Room operation started | |
| 4 | Saitama Medical Center, School of Nursing (Three-year program newly established) | |
| 5 | Medical Center Campus LAN installation and operation started | |
| 10 | Ordering system - Central Blood Collection Room opened | |
| 10 | Saitama Prefecture Disaster Base Hospital designation | |
| 1998 | 4 | Higashi-Iruma Medical Association Disease Examination Collaboration Project |
| 8 | ME service department opened | |
| 1999 | 3 | Saitama Medical Center, School of Nursing (Two-year program canceled) |
| 3 | Department of Emergency and Critical Care Medicine designation | |
| 6 | Insurance Consultation Guidance Office established | |
| 10 | Visiting Nursing Station opened | |
| 2000 | 3 | Medical records disclosure started |
| 3 | Casa Almuino opened | |
| 4 | Center for Maternal-Fetal and Neonatal Medicine expanded (92 beds: Total beds 884) |
|
| 6 | Increase in beds (25 beds) | |
| 12 | Sterile room opened (4 beds: Total beds 913) | |
| 12 | Medical safety control room established | |
| 2001 | 4 | Disease examination cooperation room established |
| 6 | Medical Information Room established | |
| 2002 | 1 | Nursing Care Support Center established |
| 2 | Lynak expansion work completed | |
| 2003 | 5 | Casa Almuino II opened |
| 2004 | 3 | Saitama Medical Center, School of Nursing New school building completed (3-year course/capacity 80 people) |
| 2005 | 6 | Japan Medical Function Evaluation System Certification acquired Certification No. JC552 (Examination system Category 4 (Ver. 4.0) |
| 2006 | 4 | 5th Floor Central Ward opened |
| 10 | Outpatient Chemotherapy Room opened | |
| 2007 | 1 | Base Hospital for Cancer Treatment Collaboration designation |
| 1 | Faculty Research Building opened | |
| 8 | Infection Control Room - Bedsore Prevention Office established | |
| 10 | Medical helicopter operations started |
|
| 2008 | 3 | New Nurses Dormitory (Margaret III) completed |
| 4 | Cancer Care Support Office - Palliative Care Office established | |
| 5 | Cell Preparation Room - Cell Therapy Preparation Room established | |
| 2009 | 3 | Kawagoe Nursery School "Tsubasa" - New Kindergarten building completed |
| 2010 | 10 | Japan Medical Function Evaluation System Certification Certification No. JC552 (Examination system Category 4 (Ver. 6.0) |
| 2010 | 12 | Increase in beds (3 beds) (Total beds 916) |
| 2013 | 1 | Center for Maternal-Fetal and Neonatal Medicine expanded (75 beds: Total beds 991) |
| 2013 | 3 | New Nurses Dormitory (Margaret V) completed |
| 2013 | 5 | Medical helicopter hanger completed |
| 2013 | 7 | Special high voltage substation updated |
| 2014 | 6 | Patient Support Office established |
| 2015 | 6 | Management building completed |
| 2015 | 6 | Japan Medical Function Evaluation System Certification acquired Certification No. JC552-3 (Functional type version evaluation item 3rd G: Ver. 1.1) |
| 2015 | 12 | 2nd Research Building opened |
| 2016 | 2 | 30th Anniversary Ceremony of the opening of the Medical Center |
| 2016 | 3 | Department of Emergency and Critical Care Medicine new building opened - Pediatric Intensive Care Unit designation |
| 2017 | 4 | Ward renovation work started |
| 2017 | 4 | Endoscopy Center opened |
| 2017 | 4 | Ultrasound Center opened |
| 2017 | 4 | Cerebral Vascular Center opened |
| 2017 | 5 | Organ Transplant Center opened |
| 2017 | 7 | Blood Purification Center opened |
| 2017 | 8 | Outpatient Chemotherapy Center opened |
| 2017 | 10 | 2nd Floor West Ward opened |
| 2018 | 1 | "Tea Room" opened |
| 2018 | 2 | Kawagoe City Emergency WS (Workstation) signed |
| 2018 | 4 | Emergency Generator Room completed |
| 2018 | 4 | Center for Cancer Genomics and Advanced Therapeutics designation acquired |
| 2018 | 5 | Kawagoe City Emergency WS (Workstation) operation started |
| 2019 | 4 | Department of Pediatric Cardiovascular Surgery opened |
| 4 | Department of Palliative Medicine opened | |
| 4 | Department of Clinical Genetics opened | |
| 4 | Department of Palliative Medicine center opened | |
| 4 | Patient Support Office center opened(Hospital and Clinic Collaboration Office、 Medical Welfare Counseling、Cancer Counseling Support Center)Pressure Support team、 pressure ulcer care team 、foot care team |
|
| 4 | staff health management department opend | |
| 4 | training management department opend | |
| 4 | hospital management scheme room opend | |
| 9 | regional medical care support hospital designation | |
| 2020 | 3 | core disaster base hospital designation |
| 6 | da Vinci(robotic-assisted surgery) started | |
| 2021 | 4 | urinate care team started |
| 4 | COVID-19 patient receipt Key medical institution designation | |
| 2022 | 3 | medical practice professor hospital designation |
| 3 | da Vinci(robotic-assisted surgery) expanded | |
| 5 | Postoperative Pain management team started | |
| 2023 | 4 | Inflammatory bowel disease center staeted |
| 2024 | 9 | Casa Almuino Ⅲ opened |
| 10 | hybrid Operating room(X-ray)started | |
| 11 | outpatient center started | |
| 11 | Physical restraint Minimization team started | |
| 11 | Psychiatry Liaison team started | |
| 2025 | 1 | da Vinci(robotic-assisted surgery) expanded |
| 3 | trauma center started | |
| 3 | Staff Training and Support Center started |